Repurposing Drugs in Oncology

Wanna know what all these drugs have in common?

They’re all anti-parasitic

And

They’re all anti-cancer

Weird coincidence, eh?

(What it cures already exist)

Moxidectin induces Cytostatic Autophagic Cell Death of Glioma Cells through inhibiting the AKT/mTOR Signalling Pathway

https://www.jcancer.org/v11p5802.htm

Moxidectin induces Cytostatic Autophagic Cell Death of Glioma Cells through inhibiting the AKT/mTOR Signalling Pathway

https://pubmed.ncbi.nlm.nih.gov/32913473/

The anthelmintic agent oxfendazole inhibits cell growth in non‑small cell lung cancer by suppressing c‑Src activation

https://www.spandidos-publications.com/mmr/19/4/2921

Ivermectin Antiparasitic Anticancer Wonder Drug

Ivermectin Antiparasitic Anticancer Wonder Drug

The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/

Unexpected antitumorigenic effect of fenbendazole

https://pubmed.ncbi.nlm.nih.gov/19049251/

A Drug For Animals Now Taken By Humans For Cancer: Fenbendazole

A Drug for Animals Now Taken by Humans for Cancer: Fenbendazole

The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458798/

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255490/

Mebendazole as a Candidate for Drug Repurposing in Oncology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769799/

Niclosamide Exhibits Potent Anticancer Activity

https://pubmed.ncbi.nlm.nih.gov/29843133/

Molecular mechanisms of niclosamide antitumor activity

https://pubmed.ncbi.nlm.nih.gov/26716739/

Niclosamide: Beyond an antihelminthic drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628105/

Oxibendazole inhibits prostate cancer cell growth

https://www.spandidos-publications.com/ol/15/2/2218

Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents

https://pubmed.ncbi.nlm.nih.gov/29225688/